weight loss after stopping methimazole

This content is strictly the opinion of Dr. Westin Childs and is for educational and information purposes only. Maintaining a healthy diet and staying active will aid in weight loss while you take Tapazole. Advertising on our site helps support our mission. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, Low blood counts, like low white cell counts, An unusual or allergic reaction to methimazole, other medications, foods, dyes, or preservatives, Certain medications for high blood pressure, heart disease, irregular heartbeat like metoprolol and propranolol, Allergic reactionsskin rash, itching, hives, swelling of the face, lips, tongue, or throat, Infectionfever, chills, cough, or sore throat, Liver injuryright upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue, Low thyroid levels (hypothyroidism)unusual weakness or fatigue, increased sensitivity to cold, constipation, hair loss, dry skin, weight gain, feelings of depression, Unusual weakness or fatigue, fever, headache, skin rash, muscle or joint pain, loss of appetite, pain, tingling, or numbness in the hands or feet. pale skin, easy bruising, unusual bleeding. Treatment of hyperthyroidism commonly results in weight gain, but the extent of weight gain is not well known. redness of the face, neck, arms, and occasionally, upper chest. This can obviously be confusing for patients, but it doesnt have to be. Restart Medical LLC. I wqas put on 15 mg of Methimazole and about three weeks later I stated puting on weight and was perfectly fine. Initial dose: Mild hyperthyroidism: 15 mg orally per dayModerately severe hyperthyroidism: 30 to 40 mg orally per daySevere hyperthyroidism: 60 mg orally per day Maintenance dose:5 to 15 mg orally per day Comments: Daily doses are usually given in 3 divided doses at approximately 8 hour intervalsUses: -For the treatment of Graves' disease with hyperthyroidism or toxic multinodular goiter in whom surgery or radioactive iodine therapy is not an appropriate treatment option.-To ameliorate symptoms of hyperthyroidism in preparation for thyroidectomy or radioactive iodine therapy. The mechanism is not completely understood, but the presentation suggests an immunological mechanism. Its also well known that having low T3 (a side effect of taking methimazole) may lead to weight gain as well. Avoid being near people who are sick or have infections. If you miss a dose, take it as soon as you can. Throw away any unused medication after the expiration date. will methimazole be of benefit? . Hyperthyroidism can cause thinning bones, states MayoClinic.com. You can lose weight on methimazole, but you have to be consistent! It's not impossible to lose weight while taking methimazole but it is very difficult. I'm Westin Childs D.O. Certain diseases are particularly dangerous and harm our bodies in other ways. Why Do My Knees Hurt When I Start Losing Weight? So does it make sense that you can put someone on a thyroid blocker like methimazole and expect to perfectly balance thyroid hormone in the body? If you skip or stop your medicine entirely, you can experience a number of short-term and long-term consequences, including: Debilitating weight loss Dramatically increased appetite and thirst Nervousness, anxiety, panic attacks Heat intolerance, sweating Fatigue or muscle weakness Diarrhea, nausea, and vomiting Irregular menstrual cycle Available for Android and iOS devices. A primary mechanism of Methimazoles action appears to be its interference with thyroid peroxidase (TPO), which is an essential step in thyroid hormone synthesis. Aim for 1,000mg per day for adults under the age of 50 and 1,200mg for adults over 50. Methimazole, the main reason for increasing weight during treatment of Hyperthyroidism, causes about 10% of patients to gain weight during and after the treatment. The molecular weight is 114.16, and the molecular formula is C 4 H 6 N 2 S. The structural formula is as follows: Patients who had surgery were not included in the study so we do not have a comparison. methimazole is not a steroid..im hyperthyroid 2018..i lost 10 pounds..started methimazole and gained what i lost..its bec when your hyper you burn so fast..everything from muscles to bones to heart to metabolism..so if you take methimazole your thyroid will become well again..so you will gain the pounds that you lost.. We want the forums to be a useful resource for our users but it is important to remember that the forums are Table of Contents | PDF File for Saving and Printing, HYPERTHYROIDISM It is essential to explain Graves disease since it is the leading cause of Hyperthyroidism, and you can use Methimazole to treat it. When optimizing thyroid function make sure you shoot for the optimal lab tests which you can find here. Myositis is an infrequently encountered side effect of which physicians should be aware in a hyperthyroid patient with muscle complaints. Talk to a dietitian about creating a meal plan that has a high nutritional value and fewer calories, says MayoClinic.com. Run on the treadmill for one minute and walk for two minutes. All rights reserved. It is best to consult your healthcare provider if there is excessive weight loss. Reducing the dosage will not help that much, perhaps a little, but still a steroid and that's sometimes what they give patients that can not gain weight. How can you gain weight if you have hyperthyroidism? A Community for those living with and dealing with Graves' Disease. After stopping Methimazole, there could be a variety of reasons for weight loss. Answer: The absence or discontinuation of antithyroid medications will produce unbelievable and undesirable effects. Men gained on average 17.6 lbs and women gained about 12.1 lbs. The symptoms resolved completely within 3 weeks. Ive been really watching what I eat and exercising, and my weight hasnt budged. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Usual Pediatric Dose for Hyperthyroidism: Initial dose: 0.4 mg/kg orally per dayMaintenance dose: 0.2 mg/kg orally per day (approximately half the initial dose) Comments: Daily doses are usually given in 3 divided doses at approximately 8 hour intervals. As for polymyositis associated with Graves' disease, it is uncommon and occurs in the background of a positive family history of autoimmune diseases and positive antinuclear antibodies (2). By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. This study showed that among 42 patients with Graves disease that the average weight gain was around 12 pounds after starting methimazole. This content does not have an English version. From undetectable TSH to now normal range. Medically reviewed by Drugs.com. Yes, hair loss (alopecia) is listed as a side effect of methimazole (brand name: Tapazole) and other thyroid medications. Data sources include IBM Watson Micromedex (updated 1 May 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Carbimazole induced ANCA positive vasculitis, Journal of Association of Physicians of India, Endocrinology, Diabetes & Metabolism Case Reports, Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The patient received only symptomatic treatment with nonsteroidal anti-inflammatory drugs. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Furthermore, each medicine works differently. All rights reserved. Side effects may include fluid retention, weight gain, elevated blood sugar levels, increased blood pressure and mood swings. It means that it is entirely possible that taking methimazole may block the normal thyroid function in the body and lead to weight gain. Step 1 Consult your physician before starting to restrict calories. 1). Hyperthyroidism weight gain after treatment is a common side effect. Medically reviewed by Drugs.com on Feb 20, 2023. Average weight gain was about 11.8 lbs for patients who were treated with medication, 12.3 lbs for those who had RAI treatment without developing hypothyroidism, and 15.6 lbs for those who had RAI treatment and developed hypothyroidism. Include exercises like squats, push-ups, triceps dips and biceps curls for three sets of 15 repetitions. It has also been shown, in aminal studies, that long-term use of methimazole may cause weight gain and other harmful side effects to the body (4). If you need surgery, tell the surgeon ahead of time that you are using methimazole. Try our Symptom Checker Got any other symptoms? The reason for regular weight loss is the stable amount of hormones produced. Use of the forums is subject to our Terms of Use At my high point of GD, I was down to 124 and then gradually back up to 139 after starting MMI. While this medication may be prescribed for children for selected conditions, precautions do apply. BACKGROUND Hyperthyroidism occurs when there is too much thyroid hormone in the blood. The chemical formula is C 4 H 6 N 2 S. Molecular weight is 114.16. I recently got the go-ahead to stop taking it and was wondering if I could expect to lose some of the 18 lbs I gained in the year while on the medicine, or whether this is probably my stable weight now that I've . This balance may be difficult to achieve with methimazole, but it is always worth attempting. But blocking thyroid production, in a perfect way, is easier said than done. I have 8lbs more to lose and hope to achieve this by May 2020. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). It works by interfering with thyroid hormone production, that is what slows your metabolism and causes weight gain. Methimazole is used to treat hyperthyroidism (overactive thyroid). It works by decreasing the amount of thyroid hormone your body makes. Hyperthyroidism: a condition where the thyroid gland is overactive and produces too much thyroid hormone. We know from studies such as this, that it is NOT uncommon for patients to gain around 5kg or 12 pounds when they start methimazole (5). #1. https://www.ncbi.nlm.nih.gov/pubmed/24692351, #2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817786/, #3. https://www.ncbi.nlm.nih.gov/gene/7173, #4. https://www.ncbi.nlm.nih.gov/pubmed/28759749, #5. https://www.ncbi.nlm.nih.gov/pubmed/22990640, #6. https://www.ncbi.nlm.nih.gov/pubmed/19341475, #7. https://www.ncbi.nlm.nih.gov/pubmed/19432125, #8. https://www.ncbi.nlm.nih.gov/pubmed/11531931, #9. https://www.ncbi.nlm.nih.gov/pubmed/12939927. Written informed consent was obtained from the patient/patient's mother for publication of this case report. Methimazole can also, without delay, inhibit TPO. National Library of Medicine Myositis is not a classical feature in either situation. The answer is yes, but it may be more difficult. It made me feel really sluggish but after removal of my thyroid last May I feel lots better and now only take levothyroxine daily. Adthyza Thyroid Medication Review: Should You Use it. Need better symptom control? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Mayo Clinic does not endorse companies or products. Side effects that you should report to your care team as soon as possible: Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): This list may not describe all possible side effects. This is not a complete list of side effects and others may occur. Polymyositis after propylthiouracil treatment for hyperthyroidism, Carbimazole-related myositis in a Chinese woman, QJM: Monthly Journal of the Association of Physicians, Elevation of creatine kinase during medical treatment of Graves's disease, Murata K, Sugie K, Takamure M, Fujimoto T & Ueno S. 2003, Eosinophilic major basic protein and interleukin-5 in eosinophilic myositis, Wang LC, Tsai WY, Yang YH & Chiang BL. Graves' disease was diagnosed . It is additionally used before thyroid surgery or radioactive iodine treatment. 3 years ago, Egton Medical Information Systems Limited. Check with your doctor immediately if any of the following side effects occur while taking methimazole: Some side effects of methimazole may occur that usually do not need medical attention. Two weeks after stopping methimazole, the fever reappeared associated with left gluteal swelling and mild erythema over the involved area. Some side effects may occur that usually do not need medical attention. Studies have suggested that the risk of agranulocytosis is greater in older patients and that they have a higher rate of death. METHIMAZOLE (meth IM a zole) treats high thyroid levels (hyperthyroidism) in your body. You have to consider that you will be at a disadvantage trying to lose weight if your thyroid is being blocked. However, the causal relationship between the therapy and the skin defect is controversial, and anomalies related to methimazole have low birth prevalence. S Sissi, N El Kara, and G Abdallah were involved in data collection and hospital care. My hair loss slowed down significantly and overall I've been feeling very good. Accessibility Protect from light. Antibodies to double-stranded DNA are detectable in <5% of drug-induced lupus (7). Keep tightly closed. Sometimes it may be possible to simply reduce your dosage which will allow some thyroid hormone activation and production in your body. Several conditions can cause it, including Plummers disease, Graves disease, and thyroiditis. The most common cause of hyperthyroidism in the United States is Graves' disease. Gestational diabetes, high levels of blood sugar during pregnancy . feeling of constant movement of self or surroundings, general feeling of discomfort, illness, or weakness, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, feet, or lower legs, swollen, painful, or tender lymph glands in the neck, armpit, or groin, pain or discomfort in the chest, upper stomach, or throat. An official website of the United States government. Weight loss is average as long as it is not excessive. Exercise regularly. Common side effects of Tapazole include rash, itching, hives, abnormal hair loss, skin pigmentation, swelling, nausea, vomiting, heartburn, loss of taste, joint or muscle aches, numbness, and headache. For more information, please see our You may lose up to 5 pounds within the first month you start taking Methimazole. This slows down the metabolic processes in your body, which reduces excess weight and fat mass (like belly fat). [Ref], Frequency not reported: Skin rash, urticaria, abnormal loss of hair, pruritus, skin pigmentation[Ref], Frequency not reported: Arthralgia, myalgia[Ref], Frequency not reported: Paresthesia, loss of taste, headache, drowsiness, neuritis[Ref], Frequency not reported: Nausea, vomiting, epigastric distress, sialadenopathy, Postmarketing reports: Acute pancreatitis[Ref], Case reports for recurrent acute pancreatitis with a decreased time to onset after re-exposure to carbimazole/thiamazole (methimazole) have been received. R Bou Khalil and M Abou Salbi were involved in data collection, patient care, and follow-up. Some of the important ones are below: When we observe that your weight loss is not average, or if your body is losing weight exponentially. Two weeks after stopping methimazole (on admission to the hospital) Two months after stopping methimazole; TSH: 0.35-4.94 <0.005: 0.0001 <0.0005: Free T 4: 0.7-1.48 ng/dl: 2.6 . The risk of weight gain can be very scary, however, hyperthyroidism needs to be treated otherwise it can become very severe and even lead to deadly complications. The comparison group without thyroid disease had 10,984 participants. This means that general exercise and dieting is usually not sufficient to effect significant weight loss in the person. Have you been able to lose weight despite it being difficult? official website and that any information you provide is encrypted The muscle biopsy characteristically shows marked atrophy with a predominantly lymphocytic infiltrate (1). Methimazole Shouldn't Be Used Long-Term If you are taking methimazole then you should be aware that this medication is NOT intended to be used long-term. You can treat Hyperthyroidism in several ways. This thyroid hormone, released from the thyroid gland, causes the activation of thyroid hormone receptors in the body. Treatment of hyperthyroidism commonly results in weight gain, but the extent of weight gain is not well known. Some related it to a direct effect of carbimazole on muscle (5) and others related it to a rapid decrease in thyroid hormones resulting in a relative local hypothyroid state within the muscle, which may contribute to the creatine phosphokinase elevation (5). People with Hashi's are extremely sensitive to both the thyroid-blocking meds and the thyroid hormone replacement meds. Methimazole was stopped. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. It does this by blocking an enzyme known as thyroid peroxidase(3) which is responsible for producing thyroid hormone. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Can You Use Neosporin for Anal Fissure: Is It Effective? (former Osteopathic Physician). Home Patients Portal Clinical Thyroidology for the Public March 2020 Vol 13 Issue 3 p.3-4, Summaries for the Public from recent articles in Clinical Thyroidology Low thyroid levels (hypothyroidism)unusual weakness or fatigue, increased sensitivity to cold, constipation, hair loss, dry skin, weight gain, feelings of depression. Radioactive iodine (RAI): this plays a valuable role in diagnosing and treating thyroid problems since it is taken up only by the thyroid gland. Thyroid 29:13801389. Two weeks later, he developed a febrile illness. The treatment of hyperthyroidism is to BLOCK thyroid hormone. The dose is taken in 3 divided doses every 8 hours. as being in breach of those terms. Methimazole is a reason for the increasing weight of patients during hyperthyroidism treatment. Not really, at least not for every person. Has anyone experienced weight loss after reducing their methimazole dose? and transmitted securely. Three months ago, my doctor reduced dose to 10 mg. Methimazole can absolutely cause weight gain and it does this by blocking thyroid function and activation in the tissues in your body. Graves' disease was diagnosed (Table 1). Blood and urine cultures were negative. If anyone has any personal experience with this, any info is appreciated. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. E Azar, M Khoury, and S Farhat were involved in patient assessment, diagnosis, and treatment. Tapazole (methimazole) is a thyroid medication used to treat an overactive thyroid gland (hyperthyroidism) and decrease hyperthyroidism symptoms in preparation for surgical removal. 7 users are following. It absolutely can, and it does this by slowing down your metabolism and reducing the amount of energy that the body produces at baseline. Animal studies do not always cross over perfectly with humans, but they can still act as useful tools that we can learn from. Hyperthyroidism is a medical condition that results in excessive thyroid hormone production in the body. Some of the important ones are below: Stop using Methimazole before proper treatment: If you stop taking Methimazole before Hyperthyroidism is cured, you will lose a lot of weight. Pass volumes of urine at night. In addition to methimazole binding to thyroglobulin without delay, direct inhibition of thyroglobulin itself has been proposed. Cases of myositis were described with thionamides in which there was an immune-mediated mechanism, with either drug-induced lupus (7) (8) or ANCA-positive vasculitis (9). Because of the way that thyroid function is naturally regulated by the body, it is much more difficult to try and normalize thyroid function with thyroid hormone replacement medication. I had an issue too..the pills helped but the weight gain wasn't all that great. And this should actually make perfect sense once you understand the physiology.

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