high platelet count during pregnancy

1, and Table S4A in the Supplementary Appendix). Gernsheimer T, James AH, Stasi R. How I treat thrombocytopenia in pregnancy. Thrombocytopenia at delivery: a prospective survey of 6715 deliveries. Inflamm Bowel Dis. Please refer to our Privacy Policy to change your cookie settings. Many women who have HELLP syndrome need to give birth early to prevent health complications. Among all 15,723 deliveries that occurred at Oklahoma University Medical Center (OUMC) between January 1, 2011, and August 19, 2014, a total of 7351 women who had a platelet count measurement at the time of delivery and at least one platelet count measurement during their pregnancy were selected for inclusion in our study. That means you have the same number of platelet cells in a larger volume of blood. Delivering the fetus early may also be recommended. Platelet counts may be even lower in women with pregnancy-related complications. Fetal intrauterine growth retardation (IUGR) complicates approximately four percent of pregnancies in women with essential thrombocytosis, Anil states. Vaccine . Beginning in 1993, three large studies documented that 5 to 10% of women who had uncomplicated pregnancies had a platelet count of less than 150,000 per cubic millimeter at the time of delivery,13 which was described as gestational thrombocytopenia.4 The normal distribution of platelet counts at the time of delivery and the absence of health problems in the mother and infant suggested that gestational thrombocytopenia was the result of lower platelet counts that occur in all women during pregnancy.2,3,5,6 The current thinking is that platelet counts in all women begin to decrease in the mid-second to third trimester and continue to decrease until the time of delivery.4 However, our recent systematic review of published reports that describe platelet counts throughout uncomplicated pregnancies did not provide support for this concept.7 The number of published reports that we were able to identify was few, and their results were inconsistent. Examples include: Research has found that urinary tract infections, respiratory infections, and gastrointenstinal infections are among the leading causes of a high platelet count. 2-4 However, counts < 100 10 9 /L, which is the definition for thrombocytopenia adopted by an International Working Group, 5 are observed in only 1% of pregnant women. When we evaluated all 10,296 platelet count values measured during pregnancy and at the time of delivery in women with pregnancy-related complications (Fig. Preexisting disorders that were considered to be associated with thrombocytopenia were recorded as immune thrombocytopenic purpura, systemic lupus erythematosus, human immunodeficiency virus infection, and hepatitis B or C. Women who did not have these pregnancy-related complications or preexisting disorders were considered to have had uncomplicated pregnancies even though they could have had other diagnoses that could be considered as complicating a pregnancy, such as a history of treated cancer. He was a physician in the US Air Force and now practices at MD Anderson Cancer Center, where he is an associate professor. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. In most cases, this is not something to worry about as it tends to resolve on its own a few weeks after birth. Increased platelet volume is indicative of younger platelets, suggesting some increase in platelet turnover in pregnancy. official website and that any information you provide is encrypted doi:10.3399/bjgp20X710957, Manne BK, Denorme F, Middleton EA, et al. Multiple physiological changes during pregnancy may contribute to lower platelet counts. . Last reviewed by a Cleveland Clinic medical professional on 05/12/2021. X 10 9 /L. But when that count drops abnormally low, there are several potential causes. You can increase your chances of having a healthy pregnancy by: Untreated HELLP syndrome can lead to serious complications, including: HELLP syndrome is rarely life-threatening. Are you at risk for clots? Ananth CV, Oyelese Y, Yeo L, Pradhan A, Vintzileos AM. In certain cases, increased platelet count can give rise to serious complications as a result of unexplained blood clotting. A total of 7 of the 25 women (28.0%) who had HELLP syndrome had a platelet count of less than 80,000 per cubic millimeter (median, 61,000; range, 32,000 to 78,000). It really depends on the laboratory range provided by individual labs as well. Read More Created for people with ongoing healthcare needs but benefits everyone. Treatment will vary depending on the underlying cause, and in some cases, may not be necessary. Cleveland Clinic is a non-profit academic medical center. A novel approach to the assessment of variations in the human platelet count. In some cases this is due to a problem that existed prior to pregnancy; in others, it comes on during pregnancy. Dhaliwal G, Cornett PA, Tierney LM. 2014;124(2):184-7. doi:10.1182/blood-2014-03-562538. These tests may include: A high platelet count may be worrisome if: In general, blood clots tend to be linked to primary thrombocytosis. An official website of the United States government. A very high platelet count can cause blood clots that can block blood flow to your baby. Up to 1 in 5 women who have HELLP syndrome experience it a second time. There are many types of anemia, a condition in which your blood doesn't have enough healthy red blood cells. Neutrophils can also demonstrate a "left shift" (increased number of band neutrophils). The mean platelet count during the postpartum period did not differ significantly between the women with uncomplicated pregnancies and the nonpregnant women (P = 0.10). Women who have preeclampsia or eclampsia (uncontrolled preeclampsia) have a higher risk of HELLP syndrome. When this stress hormone is released, it impacts several organs, including the spleen, which filters blood and stores platelets. Copyright 2023 Leaf Group Ltd., all rights reserved. We offer women's health services, obstetrics and gynecology throughout Northeast Ohio and beyond. Use of multiple inflammatory marker tests in primary care: using clinical practice research datalink to evaluate accuracy, Etiology of thrombocytosis in a general medicine population: analysis of 801 cases with emphasis on infectious causes, Effects of physical (in)activity on platelet function, Stress enhances proinflammatory platelet activity: the impact of acute and chronic mental stress, Pathophysiology, classification, and complications of common asymptomatic thrombocytosis in newborn infants, Clinical course and short-term outcome of postsplenectomy reactive thrombocytosis in children without myeloproliferative disorders: A single institutional experience from a developing country, A review and assessment of drug-induced thrombocytosis, Cancer incidence following a high-normal platelet count: cohort study using electronic healthcare records from English primary care, Platelet gene expression and function in patients with COVID-19, Iron panel to show how much iron is present, Blood testing to check for specific gene mutations, Short-term conditions, such as an infection or inflammation. We evaluated platelet counts throughout pregnancy in women who delivered at Oklahoma University Medical Center between 2011 and 2014. doi:10.1371/journal.pone.0237016, Vo QT, Thompson DF. If you need treatment, your treatment plan will depend on the type of platelet disorder you have and what is causing your condition. The interaction between the mean platelet count in the women with uncomplicated pregnancies and the mean platelet count in the women with pregnancy-related complications was significant (P = 0.002), which indicated that the rates of decrease in platelet counts differed. Test results can also help find out what type of platelet disorder you have. However, HELLP syndrome itself does not affect the newborns liver function or other organs. Platelet counts in all women decrease throughout pregnancy, beginning in the first trimester. Reese JA, Peck JD, McIntosh JJ, Vesely SK, George JN. This stratified analysis accounted for any differences in platelet counts on the basis of race or ethnic group or age between the nonpregnant women from NHANES and the pregnant women. Etiology of thrombocytosis in a general medicine population: analysis of 801 cases with emphasis on infectious causes. Your healthcare team will make sure that your treatment plan is safe for you and your baby. Based on the research I did, they could choose to put you on steroids to increase platelet production or give you a platelet infusion. Severe IUGR can lead to intrauterine death. Among the 246 women with uncomplicated pregnancies who were assessed during the postpartum period, the mean platelet count was 17% lower at the time of delivery than during the postpartum period (218,000 vs. 264,000 per cubic millimeter). A high platelet count is associated with certain kinds of cancer, including: The most common cancers to cause a high platelet count include gastrointestinal cancer, lymphoma, ovarian cancer, lung cancer, and breast cancer. Julie is an Adult Nurse Practitioner with oncology certification and a healthcare freelance writer with an interest in educating patients and the healthcare community. government site. Here's what you need to know. HELLP syndrome is very rare that occurs in 0.1% to 1% of pregnancies. Thrombocythemia and thrombocytosis. Platelet counts in healthy women and men are genetically determined and exhibit little variation over time.15 Therefore, women whose platelet counts are at the low end of the normal range when they are not pregnant are more likely to have platelet counts that are below the normal range during pregnancy. Since your gynae suggested u to go for further tests, pls go ahead, anyways its just a blood check and it will give u piece of mind. What are platelets and why are they important? Biomed Res Int. Your healthcare team will monitor your platelet count and other, Separation of the placenta from your womb, Obesity, Nutrition, and Physical Activity, Thrombotic Thrombocytopenic Purpura (TTP). When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Treating the anemia should help return your platelet levels back to normal. The difference in the mean platelet count between the women who had no missing platelet counts and the 4232 women who had missing platelet counts during one or more trimesters was not significant (P = 0.79). Platelet counts may be even lower in women with pregnancy-related complications. It is a type of preeclampsia. 2020;70(698):e622-e628. Sepsis and preeclampsia can both cause high platelet volume with low platelet count. 102: management of stillbirth. Fetal intrauterine growth retardation (IUGR) complicates approximately four percent of pregnancies in women with essential thrombocytosis, Anil states. 2014 Apr;99(4):620-8. doi:10.3324/haematol.2013.092684, Zvizdic Z, Kovacevic A, Milisic E, Jonuzi A, Vranic S. Clinical course and short-term outcome of postsplenectomy reactive thrombocytosis in children without myeloproliferative disorders: A single institutional experience from a developing country. Among women who had one of the other three disorders, 1.4 to 6.0% had platelet counts below 80,000 per cubic millimeter (Table S4B in the Supplementary Appendix). You may also have to see a hematologist, a doctor who specializes in blood disorders. Previous labor and delivery, with risk increasing for women who have given birth more than once before. A total of 59 women with pregnancy-related complications (2.3%) had platelet counts of less than 100,000 per cubic millimeter during pregnancy or at the time of delivery. 190: gestational diabetes mellitus. Haram K, Svendsen E, Abildgaard U. However, the occurrence and severity of thrombocytopenia throughout pregnancy are not defined. Pregnancy can cause your platelet count to be slightly lower than normal. When to Worry About High Platelet Count. Nishio et al. If normal, then there is no need to worry. Preterm delivery, or delivery before 37 weeks of pregnancy, occurs in eight percent of cases of thrombocytosis in pregnancy, according to Anil. The mean platelet counts in these women decreased significantly throughout pregnancy (P<0.001) and were lower in all three trimesters and at the time of delivery than the mean platelet counts in the women who had uncomplicated pregnancies (P<0.04 for all comparisons). Leukemia and Lymphoma Society. I'm sure they're just erring on the side of caution and want you to get checked out. I bars denote 95% confidence intervals. Platelet counts of less than 150,000 per cubic millimeter at the time of delivery were more common among women who had pregnancy-related complications than among women who had uncomplicated pregnancies (11.9% vs. 9.9%, P = 0.01). Whatevers on your mind, were here to help, Copyright DANONE DUMEX. 1, and Table S4B in the Supplementary Appendix). Our objective with respect to women who had preexisting disorders associated with thrombocytopenia was to learn whether their thrombocytopenia becomes more severe during pregnancy. Belly pain, especially in the upper right side. A reactive high platelet level could be due to a whole range of causes which include: -Acute bleeding and blood loss -Allergic reactions -Cancer -Chronic kidney failure or another kidney disorder -Exercise -Heart attack -Coronary artery bypass -Infections, including tuberculosis -Iron deficiency -Vitamin deficiency -Removal of spleen -Hemolytic The name HELLP syndrome stands for: . In women who have a platelet count of less than 100,000 per cubic millimeter, a cause other than pregnancy or its complications should be considered. (Funded by the National Heart, Lung, and Blood Institute.). HELLP stands for hemolysis (the destruction of red blood cells), elevated liver enzymes and low platelet count. Among the 4568 women with uncomplicated pregnancies whom we evaluated, 529 had a subsequent uncomplicated singleton pregnancy during our period of analysis and had a recorded platelet count at the time of delivery. Share sensitive information only on official, secure websites. Our Healthcare Expert will be answering some questions every week but in the meantime, here's a little tip from our Careline! doi:10.1007/s11481-020-09945-4, Jeon, GW. The HELLP syndrome: clinical issues and management: a review. Short and long-term stress is associated with platelet aggregation, which is when they group together near an injury site. The Function of Blood Platelets or Thrombocytes, Understanding Your MPV Blood Test Results, Low Platelet Count (Thrombocytopenia) During Cancer Treatment. Jnsson V, Bock JE, Nielsen JB. Age, with risk increasing for women over 25. This is called gestational thrombocytopenia. A reactive high platelet level could be due to a whole range of causes which include: -Acute bleeding and blood loss -Allergic reactions -Cancer -Chronic kidney failure or another kidney disorder -Exercise -Heart attack -Coronary artery bypass -Infections, including tuberculosis -Iron deficiency -Vitamin deficiency -Removal of spleen -Hemolytic anemia -Inflammation, such as from rheumatoid arthritis, celiac disease, connective tissue disorders or -inflammatory bowel disease -Major surgery -Pancreatitis -Trauma -Burns -Exercise. Up to half of women who had HELLP syndrome can have some type of hypertensive disorder in her next pregnancy. We identified 3,039 studies; 46 reporting 30 women with normal pregnancies were included in our analyses. HELLP syndrome is a separate disorder from preeclampsia as patients may not have high blood pressure or proteinuria. The mean platelet counts of the 197 women who had preexisting disorders associated with thrombocytopenia were lower than those of the women who had uncomplicated pregnancies at all trimesters and at the time of delivery (P<0.03 for all comparisons).

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